Both are Asp.Net Server Side Controls,But Major Difference is Link Button having Post Back Nature,where as Hyperlink Is not having Post Back Nature it directly goes to target page By using Navigate Url Property
If you are asking the difference between the HTML hyperlink and ASP.NET Link button control then below is the answer: Answer: The purpose of both controls is same. But there is one major difference between these two, i.e. HTML Hyperlink control is an HTML control, whenever it is clicked the page navigates to the target page. ASP.NET Link Button control is a server control, whenever the user clicks on it, the request is redirected back to the server and in its response the page is navigated to the target page.