Rotation of a PictureBox relitive to the mouse

I am sorry to whoever answered this question before it somehow got deleted. But I still need an answer. I am making a game using Visual C# 2010 and I need the PictureBox of the players ship to rotate to the mouse. For example if the mouse was in the upper right hand part of the screen then the ship would be facing there also. I would like to have this answered in the simplist way possible. Thank you!