Problem while uploading excel file

Question

Hello 

I have a ASP.NET project  deployed at server. In one module i have to upload excel file to the server. 

This project is running fine when I am using it locally but when I upload to the web server (host server) and I try to upload the excel file it give me following error .

Access to the path 'D:\INETPUB\VHOSTS\Mysite.com\Book1.xlsx' is denied.