.net 2008 remoitng

Question

When I started to work with this application and saw the statement, "RemotingConfiguration.Configure("Ap24.allusers.exe.config",  false);", I knew I needed to change "theAp24.allusers.exe.config" file so the config will would point to the correct database. However after awhile, the "Ap24.allusers.exe.config" file was somehow changed to point to a different database. I know I need not change the values in the Ap24.allusers.exe.config. Was this problem caused by something about .net remoting debugging and/or the configuation manager? Could you  explain?
Can you explain how changes in the .net remoting and configuration manger affect each other? Do the affects change when you move from debug to release mode?