Assembly SampleAssembly = Assembly.Load ("Microsoft.Office.Interop.Excel, Version=12.0.0.0, Culture=neutral, PublicKeyToken=71e9bce111e9429c"); if (SampleAssembly != null) { Type type = SampleAssembly.GetType("Microsoft.Office.Interop.Excel.ApplicationClass"); Object AppClass = Activator.CreateInstance(type); //How will I get ApplicationClass object and Workbooks objects here? }